The creation of this S3 guideline meets an important need, outlined in the National Cancer Plan, with regard to screening for cervical cancer, as the guideline aims to provide important information and support for planned organized screening for cervical cancer in Germany.
The use of AM is still not so widespread in cytopathology laboratories.Īims Annual opportunistic screening for cervical carcinoma has been carried out in Germany since 1971.
Further studies with conventional cytology are needed. This technology eliminates slide-handling steps and reduces the sample space, allowing professionals to focus on diagnostic interpretation while maintaining high-level care, which can reduce false-negatives. The average sample rejection rate was ≤3.5%.ĪMs are relevant in quality control during the analytical phase of cervical cancer screening. AM use increased the detection of cellular abnormalities and reduced false-negatives. The AM diagnostic performances were statistically equal to or better than those of the manual method.
In total, 1 317 148 cytopathological slides were evaluated automatically, with 1 308 028 (99.3%) liquid-based cytology slides and 9120 (0.7%) conventional cytology smears. Of the resulting 787 articles, 34 were selected for a complete review, including three AMs: ThinPrep Imaging System, FocalPoint GS Imaging System and CytoProcessor. The terms used were "Papanicolaou test" and "Automated cytology screening" in Portuguese, English, and Spanish, in the three scientific databases (SCIELO, PUBMED, MEDLINE). This work reviewed scientific publications regarding automated cytology from the last 15 years. We performed a literature review to evaluate the feasibility of implementing AMs in laboratories. Therefore, automatic methods (AMs) of reading the Pap test have been used to improve the quality control of the exam. However, the exam presents both false-negatives and false-positives results. © 2011 Wiley Periodicals, Inc.Ĭervical cancer progresses slowly, increasing the chance of early detection of pre-neoplastic lesions via Pap exam test and subsequently preventing deaths. In conclusion, the SP + FP detected 100% of HG abnormalities in the trial set significantly reduced the rate of unsatisfactory specimens and improved the overall screening rate of detection of HG abnormalities particularly of glandular lesions when compared with other screening technologies. The overall detection rate was 93% for HG squamous lesions 89% for known HG endocervical glandular lesions and 91% for known endometrial carcinoma. In a small number of cases, the screening cytologist did not recognize the abnormality even though on review HG cells were present in fields selected by FocalPointGS™. In every one of the 47 confirmed HG cases, either HG cells were present in the microscope fields selected by FocalPointGS™ for review by the screening cytologist (46 of 47), or full screening of the slide was indicated by the FocalPointGS™ (1 of 47), confirming the effectiveness of SP + FP technology for primary screening. To further test the sensitivity of SP + FP for HG lesions, 38 SurePath slides from confirmed HG cases, without an accompanying CON, were interpolated among the routine smears. There was no statistically significant difference between SP + FP and CON for the detection of histologically confirmed high-grade (HG) lesions in the routine split sample specimens (n = 9). The rate of unsatisfactory specimens in the SP + FP arm was 0.2% compared with 4.1% in the conventional Pap smear, a significant reduction. BD FocalPoint GS™ computer-assisted screening of BD SurePath® liquid-based cervical cytology slides (SP + FP) was compared with screening an accompanying conventional cervical Papanicolaou (Pap) smear (CON) in a split sample trial of 2,198 routine specimens.
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